The Novel Synthesis of L-Hydroxyproline from D-Glutamic Acid

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منابع مشابه

The estimation of D- and L-glutamic acid in proteins.

Brand, E., Harris, M. M. & Biloon, S. (1930). J. biol. Chem. 86, 315. Challenger, F. & Simpson, M. I. (1947). Biochem. J. 41, xl. Challenger, F. & Simpson, M, I. (1948). J. chem. Soc. p. 1591. Crum Brown, A. & Fraser, T. R. (1872). Trans. Roy. Soc. Edinb. 7, 663. Du Vigneaud, V. (1942-3). Harvey Lect. 39. Du Vigneaud, V., Moyer, A. W. & Chandler, J. P. (1948). J. biol. Chem. 174, 477. Dubnoff, ...

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Synthesis of macrocyclic analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).

The syntheses of seven macrocyclic analogues of the neuroprotective tripeptide glycyl-L-prolyl-L-glutamic acid (GPE) are described. Macrocycles 6 and 7 mimic the cis conformer of GPE whereas macrocycles 2-5, 8, and 9 mimic the trans conformer of GPE. The macrocyclic peptides of well-defined geometry were prepared via Grubbs ring closing metathesis of an appropriate diene precursor. In turn each...

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The synthesis of L-ascorbic acid in the rat from D-glucuronolactone and L-gulonolactone.

Previous studies have shown that the intact carbon chain of glucose is utilized for the synthesis of L-ascorbic acid in the rat (l-3). Evidence for this precursor relationship came from experiments in which the administration of carbon land carbon 6-labeled glucose tracers resulted in the urinary excretion of n-ascorbic acid labeled predominantly in carbon 6 and carbon 1, respectively. Although...

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Synthesis of D-@-Glutamine from P-Glutamic Acid by Glutamine Synthetase*

In contrast to fi-glutamine and @glutamylhydroxamic acid, fl-glutamic acid does not possess an asymmetric carbon atom, but has, according to the nomenclature of Schwartz and Carter (2), a meso carbon atom. The present experiments were designed to determine whether glutamine synthetase distinguishes between the carboxyl groups of P-glutamic acid. It is noteworthy in this connection that the enzy...

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The metabolism of D- and L- glutamic acid in the rat.

When DL-&ltMniC acid-2-V was administered to rats by intraperitoneal injection (l), conversion to succinate via a-ketoglutarate was the primary route of catabolism. However, when glutamate was injected into the cecum of rats, carbon 2 was converted to the methyl carbon of acetate (I). Glutamic acid administered by stomach tube was metabolized by both of the above mentioned pathways (1). The pre...

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ژورنال

عنوان ژورنال: Bulletin of the Chemical Society of Japan

سال: 1974

ISSN: 0009-2673,1348-0634

DOI: 10.1246/bcsj.47.1704